Just checking in to see how you and your pup are doing and if you ended up using Seresto collars or not. After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. The benefits of Simparica. Personally, my Roughs have sensitive skin plus I have a household cat, so Id try Frontline Gold first. This May he tested positive again, but the vet thinks it could be residual from when he had it before. I just quote the ones who are knowledgeable about MDR1. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. Studies have shown that the way an ML (macrocyclic lactone) is administered to an MDR1-positve dog makes a drastic difference in how it affects them. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) In a wellcontrolled 60day US field study conducted in dogs with existing flea infestations of varying severity, the effectiveness of SIMPARICA TRIO against fleas on Day 30 and 60 visits was 99.0% and 99.7%, respectively, I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. Please let me know how the Wondercide works for you! Simparica Trio reduced live flea counts, as well as clinical signs of FAD, by 99.0% at day 30 and by 99.7% at day 60. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Perros (mutacin del gen MDR1). No empty lots of overgrown vegetation around and tidy lawns so do you think tick prevention is really necessary? However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Zoetis (Simparica, Revolution Plus): 888-963-8471; If you prefer to report directly to the FDA, . I have a unique situation. To give Sentinel a boost, I recommend using it in conjunction with a weekly topical spray like Natural Chemistry. Thank you!! Based on your recommendations, I will not use Vectra. Also what can be used for giardia? Simparica Trio (133) 133 Reviews | Answered Questions. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. Would this be your recommendation? According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. . Is this true? For the treatment and control of tick infestations with Amblyomma americanum (lone star tick) and Ixodes scapularis . We have an 11 year old tricolor rough coat collie. My Aussie/Pyrenees mix has had no issues with it, for instance. FREE delivery Tue, Mar 7. I can live with that. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. Wow! I doubt it as he was on leash and Im always watching him. Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. Thank you for this. Is this vaccine something youve heard of? Just want to do what is best for them? It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. From an MDR1 standpoint, Simparica is *technically* safe; but I am leery of it considering the FDA warning about isoxazolines (-laner medications) I discussed in the article. GestorVet es el futuro de la gestin veterinaria. It will make your dog smell absolutely yummy while protecting them from fleas, ticks, black flies, and mosquitoes. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Thanks. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. I found some good information on the Cyphenothrin in Parastar Plus in this article. Apparently, it affects certain cats with a certain gene. I read that you you used this combination with success. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Eur. Simparica Trio Chewable Tablets for Dogs. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. Fortunately, there is a DNA test that will let you know whether your dog has this mutation. Any suggestions? The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. But it doesnt hurt mammals. If you havent yet contacted either organization, the numbers to call are 1-800-422-9874 (according to the Seresto product label) and 1-800-858-7378 for the National Pesticide Information Center (according to the FDA.gov website). Matching game, word search puzzle, and hangman also available. I will try to find the article again, I stupidly didnt bookmark it. SIMPARICA TRIO killed fleas before they could lay eggs for 35 days. Options: 3 flavors. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? With seizures it's tough to pinpoint the cause (without extensive testing), so vet recommended . . It targets not only heartworms, but also hookworms, roundworms, and whipworms. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). Nexgard and Simparica. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. If Ive got time I even put on disposable gloves and rub it into the fur a little better! 5 A dog's reaction to flea bites may vary from sores and inflammation to hair loss. As an aussie, I like to assume he's an MDR1 carrier therefore can be reactive to certain meds. I went through Paw Print Genetics to save money. It covers fleas, ticks, and heart worms. However, it did make my Collies too itchy. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. However, it will not affect heartworms at all, since they do not infest the gastrointestinal tract. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. Hi! I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. WSU is the leader in identifying drugs that may be dangerous for dogs with the MDR1 mutation and can identify alternative medications and doses. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! But unless your dogs have had a problem with tapeworms (whose segments are visible to the naked eye in dogs poo), then the regular Interceptor should be fine. Nexgard Spectra. There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. Demonstrated 98.9% effectiveness against existing tick infestations in 48 hours . Is hartz ultraguard ear mite treatment for dogs safe? A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. All dogs treated with SIMPARICA TRIO were negative for D. immitis antigen and blood microfilariae at study completion on day 330. Review this. It can be used to destroy bedbugs, cockroaches, ants, and even fleas. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. Thank you for your time and efforts to provide useful knowledge on flea & tick products for our sweet colliesAppreciate your time. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. Happy to be of help! I did write this article a couple of years ago; but I have updated it several times since most recently after information came out about some fatal reactions to Seresto collars. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Simparica Trio Chewable Tablets for Dogs works to prevent heartworms as well as treat lone star ticks, black-legged ticks, Gulf Coast ticks, American dog ticks, brown dog ticks, fleas, roundworms, and adult hookworms. Your thoughts? Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. So tick protection is also a must for us. So heres the culmination of my research: information gathered from laboratory case studies, veterinarians, and Collie owners, breeders, and exhibitors. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. It is also used off-label to control sarcoptic mange and demodectic mange. So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. If you think about it, come back here and let me and other readers know what worked best for you! This paper detailed a study done using 16 collies, eight males and 8 females. For the majority of dogs, Advecta is probably fine! Im sincerely grateful!! Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Frontline Gold and Frontline Shield. Thank you for the reminder! Use ProHeart 6 in dogs 6 months of age or older and ProHeart 12 in dogs 12 months of age or older. Approved for use in dogs over the age of 8 weeks and above 2.8 lbs, please note that depending on the pest . . Simparica Trio treats and protects against harmful parasites. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. Thank you for this. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). Hi Vicki, For long-term arthritis, my vet tech friend has had a lot of success giving her senior dog a regular Glucosamine supplement. Best of luck with your girl. In a laboratory study, the product was well tolerated in dogs with a deficient multidrug-resistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Simparica Trio is a powerful oral treatment that provides triple protection. So the following month we tried Interceptor Plus and it was fine. These three are listed as a new group of drugs called Isoxazolines, and are neurotoxins. Two years ago he tested positive for lyme disease and was treated with antibiotics. Could you send the link to that article you found? Im going to order some of the organic spray to help. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Thanks. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. I just had my vet mention the mdr1 gene today in passing. Thats what I plan to use in future, when my oldest dog reaches that point. If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. Tap to zoom. User warnings Wash hands after handling the product. (Of course, skin irritation can happen with any topical product.) Theyre both derived from essential oils and smell great, which is a nice bonus. All I can tell you is that Ive personally used it for years with no adverse reactions, everyone in my local AKC Collie club has also used it without trouble, and Im not aware of negative reports that have reached the news. tratados. Are you also on Instagram, by chance? 4.11 Withdrawal period(s) I tried Seresto with my girl and she had a seizure. 1,9 And the fact is, dogs love both chews. Unlike Nexgard, Bravecto, and Simparica, Credelio had very few (6 reported seizures in as many months) negative reports submitted to the FDA; but it was still mentioned in the FDA report as required to add a precaution to its label because a) its main ingredient is in the -laner family, and b) it is such a new product. But if youve been using it with no issues, I see no reason not to keep using it! In my opinion, this spray is great combined with anything since it has repellent properties and smells delightful. I gave a mini aussie and a minnie aussie/border collie mix. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. - It is easy to administer, with no need for pre-treatment or fasting. Many veterinary clinics keep some in stock for their clients, and it is also available at online stores like 1-800-PET-MEDS or Chewy. Emily is an avid writer, blogger, and Collie lover who collects and posts stories about Collies from around the world. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. I do remember her cowering and rubbing her back against her crate after we administered anything topical! Based on my findings, Im not convinced of its superior safety. I just picked out a beautiful tri color rough collie this morning! I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Giardia can be passed to and cause diarrhea in humans. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at I did not need to try the Seresto collar. Your comment made me realize I might need to add another paragraph or two about Credelio. , Thanks for the reply! This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. Key Features of Simparica Trio. So called vet and they said topically we should try Parastar Plus. I appreciate the research in this thank you! (357 reviews) Simparica. Thanks for reply. Hope this helps! Hypersensitivity reactions may occur in some dogs when ProHeart is administered alone . ? Im leaning toward Frontline Plus based on what you wrote. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. I plan to switch him over to Trifexis also. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. PARSIPPANY, N.J. - January 04, 2022 - Zoetis today announced that the U.S. Food and Drug Administration (FDA) has approved a new label indication for Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) for the prevention of Borrelia burgdorferi infections as a direct result of . I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. For my Aussie mix, Ive had success using Advantix II. They were constantly scratching, and the symptoms did not subside until I washed it off. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. Unfortunately, the fleas are fighting back. But of course, do talk to your vet and see what they know. Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. Sarolaner is an . Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. After her first heat she went into a false pregnancy. How to use Simparica Trio. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. I didnt see the link for the drug compatibility. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. Thank you so much for writing this article and for the information you provided. So glad you found this useful! (Basically, I did the boring work to bring you the helpful information.). What do you know about this? Simparica TRIO contains three active pharmaceutical ingredients, sarolaner, moxidectin, and pyrantel pamoate. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. These four ML compounds (ivermectin, moxidectin, selamectin, and milbemycin oxide) have been officially approved by the FDA (Federal Drug Administration) and tested safe for MDR1 dogs when administered at the recommended preventative dosage. She has always had a sensitive stomach, but as she gets older, it gets worse. Dash is MDR1 mutant/normal. According to the Vet UK website, Microfilaria and adult heartworm antigen testing. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Be prepared to answer questions about whether your dog had a previous history with seizures, has any drug sensitivities, if anything else could possibly have triggered a seizure, and if she has had any seizures since the collar was removed. We took her to a vet who is very experienced with collies (she helps with a rescue) and has assured me that Simpirica Trio is safe. We love her. Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. My dog has been tested and is mutant/normal (MDR1). Hi Emily, It is the first drug that combined three active ingredients - sarolaner, moxidectin, and pyrantel. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Simparica Trio is well tolerated in dogs with a deficient multidrugresistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose 1 THE SIMPARICA TRIO RANGE INCREASING COMPLIANCE FROM 2 MONTHS PER YEAR TO 12 WITH VETPOST COULD INCREASE REVENUE BY 600% Congratulations on the new kitten. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. Oh no! I like Frank so much that I had to give him his own story. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes. The login page will open in a new tab. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. After 1 emergency vet visit and a number of consultations with our primary care vet, we took him off simparica. This is so thorough and helpful! However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. Please keep me updated if you think of it! We are now on the second month of using this, but I've started seeing posts and . I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. Thanks much for the info before I bought anything! Tap to zoom. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? The recently introduced isoxazoline, lotilaner (Credelio) for dogs falls into this same class. In a laboratory study, the product was . Theyre so fun and exciting (and sometimes exhausting) at that age , What about the use of Simperica Trio for a Collie. Additionally, it can be used to treat and control sarcoptic mange. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. 2022 Collie Chatter. Honestly, Id use it even if it was completely ineffective, because it makes my dogs smell delicious. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Hello! I recently saw the USA Today headline (I get notifications on my phone) about Seresto collars and made a mental note to read it later and update this article if need be then promptly forgot about it! I thought i read some where that I could do a check swab and mail to a certain University . It points out that flea resistance to Cyphenothrin is also widespread, and Cyphenothrins efficacy can be reduced when broken down by sunlight. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. If youre looking for something that will repel parasites, a product such as K9 Advantix II may make a good alternative. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. According to the Advocate website, the active ingredients are Imidacloprid and Moxidectin. Thank you for your article. collies. Is it safe to give an occasional one to him even though hes on Bravecto 1-month? Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin .